SEPPA 3.0—enhanced spatial epitope prediction enabling glycoprotein antigens
نویسندگان
چکیده
منابع مشابه
SEPPA: a computational server for spatial epitope prediction of protein antigens
In recent years, a lot of efforts have been made in conformational epitope prediction as antigen proteins usually bind antibodies with an assembly of sequentially discontinuous and structurally compact surface residues. Currently, only a few methods for spatial epitope prediction are available with focus on single residue propensity scales or continual segments clustering. In the method of SEPP...
متن کاملSEPPA 2.0—more refined server to predict spatial epitope considering species of immune host and subcellular localization of protein antigen
Spatial Epitope Prediction server for Protein Antigens (SEPPA) has received lots of feedback since being published in 2009. In this improved version, relative ASA preference of unit patch and consolidated amino acid index were added as further classification parameters in addition to unit-triangle propensity and clustering coefficient which were previously reported. Then logistic regression mod...
متن کاملB-cell Epitope Prediction
When a living organism encounters a pathogenic virus ormicrobe, the B cells of the immune system recognize the pathogen’s antigens by their membrane-bound immunoglobulin receptors and, in response, produce antibodies specific to these antigens. The term antigen refers to any entity—a cell, a macromolecular assembly, or a molecule—that may be bound by either a B-cell receptor or an antibody mole...
متن کاملRetraction: Structure based sequence analysis & epitope prediction of gp41 HIV1 envelope glycoprotein isolated in Pakistan
This article [1] is retracted by the Editor because the peer review process was compromised due to a referee's undeclared conflict of interest. Based on post-publication peer review the Editor cannot trust the veracity of the findings. We apologize to all affected parties.
متن کاملStructure based sequence analysis & epitope prediction of gp41 HIV1 envelope glycoprotein isolated in Pakistan
UNLABELLED BACKGROUND Gp41 is an envelope glycoprotein of human immune deficiency virus (HIV). HIV viral glycoprotein gp41, present in complex with gp120, assists the viral entry into host cell. Over eighty thousands individuals are HIV infected in Pakistan which makes about 0.2% of 38.6 million infected patients worldwide. Hence, HIV gp41 protein sequences isolated in Pakistan were analyzed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2019
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkz413